Subtitle

Filtration solutions from Cytiva

Request a sample or support

9 - 12 September, 2024

Kistamässan Exhibition & Congress Centre Kista, Sweden

Request a sample or support

Subtitle

Filtration solutions from Cytiva

Request a sample or support

19 - 22 September, 2024

Kistamässan Exhibition & Congress Centre Kista, Sweden

KUBio™ box trailer:
Rapidly deployable capacity

When and where you need it to get therapies to patients faster.

Subtitle

Simplified tagged protein purification and tag removal

With Cytiva™ Protein Select™ resin and tag

12 September, 2024

Would you like to learn more about Cytiva’s rapidly deployable mRNA manufacturing capacity?

To receive your personal voucher, please read our Terms and Conditions and simply fill out the contact form below.

Explore how the KUBio™ box trailer is revolutionizing advanced therapy manufacturing. This modular, prefabricated biomanufacturing facility is engineered for rapid deployment and scalability, making it ideal for cell and gene therapy, mRNA production, and more.

Powered by the FlexFactory™ manufacturing platform, KUBio box trailer integrates process equipment, automation, and digital solutions into a compact, GMP-compliant cleanroom environment—helping companies accelerate time-to-market and simplify tech transfer while saving on facility space.

Key Features:

  • Modular cleanroom infrastructure for advanced therapies
  • Seamless integration with FlexFactory™ bioprocessing equipment
  • Designed for speed, flexibility, and regulatory compliance
  • Ideal for cell therapy, gene therapy, and mRNA production
  • Scalable from clinical to commercial manufacturing

Class is in session


Next generation mRNA is on the rise.

Hear our own Dave Sokolowski talk about mRNA manufacturing basics.

Filtration solutions for accurate water testing

9 - 22 September, 2024

Kistamässan Exhibition & Congress Centre Kista, Sweden

Monitoring water quality relies on the measurement of different parameters, including total suspended solids (TSS) and total dissolved solids (TDS), which are the molecules and ions that remain in a water sample after filtration.

Regulations on workflows and thresholds vary depending on country, region, or city. Regardless of the location, wastewater quality testing is a long, manual process. Proper filtration is vital in this process. Whatman filters 934-AH meet US EPA Laboratory Standard Method 2540 parts C, D, and E and GF/C meet standard for EN872.

What’s the state of sustainability for biopharma?

We heard from 800 biopharma leaders for our Sustainability Review.

Watch CPI discuss their advances in mRNA via the Cytiva FlexFactory Platform

Modular manufacturing for scalable RNA-LNP therapies.

Supported by the UK Vaccine Taskforce, the Centre for Process Innovation (CPI) has established the UK’s first GMP-ready manufacturing site to support a full mRNA-LNP development and manufacturing process. .

ÄKTA go™ protein purification system

Compact liquid chromatography system to support routine protein purification in research laboratories.

The ELEVECTA™ cell line portfolio combines innovative design and deep expertise to deliver transient, packaging, and producer options that provide competitive performance, high quality, and flexibility.

  • Fit for purpose: Choose the option that makes sense for your stage, asset mix, and organizational goals.
  • Flexible: Enjoy competitive terms and the freedom to transition between cell lines as needs evolve.
  • Enhanced product quality*: Minimize host cell DNA inside capsids, which is resistant to nucleases.
  • Innovative: Access advances in cell line engineering informed by deep industry know-how.
  • Collaborative: We’re more than a supplier. Benefit from a comprehensive suite of regulatory support services designed to expedite your success in advancing to and through clinical trials.

Product specifications

ÄKTA go™ protein purification system

Throughput Up to 300 units per load / 1200 units per 8-hour shift
Pump type Peristaltic pump
Fill Volume Range 1.0 – 50 mL
In-process control Programmable up to 100% of units
Product contact materials Single-use flow path assembly
Interior classification ISO 5 / Grade A
Cleanroom classification ISO 8 / Grade D
Dimensions 1.7 x 1.5 x 2.2 m (5’6” x 4’9” x 7’2”)
Required cleanroom space 15m² (160 sq. ft.)
Electrical 208–240 VAC, single phase, 50–60 Hz, FLA 36

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Praesent tellus neque, maximus sit amet mauris in, fermentum pharetra ante. Sed sit amet nibh commodo, fringilla lectus ac, dictum velit. Aliquam cursus feugiat congue. Aenean sit amet enim massa. Praesent mollis sagittis est, ut accumsan eros lobortis id. Maecenas at libero ex. Proin quis est vitae tortor ullamcorper pretium eu non nunc. Quisque at lacus accumsan, finibus sapien ac, viverra ligula. Donec commodo bibendum elit sit amet posuere. Curabitur rutrum pharetra nisl, vitae tincidunt ante consectetur et.

mRNA production using the Wave25 rocker

The intensification of interest in mRNA has spurred the demand for mRNA manufacturing capabilities. We will show that the ReadyToProcess WAVE™ 25 Rocker system offers a complete platform for the GMP linearization of template DNA and subsequent production of mRNA..

mRNA lipid nanoparticle encapsulation and purification

Our work showed:

  • An enhanced green fluorescent protein (eGFP2) mRNA encapsulation process that successfully scaled up to a production batch size of 49 L (1.9 g).
  • A downstream purification process that successfully scaled to an output batch size of 15 L (1.6 g) of final product.
  • A formulation step with a 94% mRNA recovery.
  • A A TFF purification step with a yield > 100%.

Bionova Scientific expands capacity and enters advanced therapies market

Bionova Scientific, a contract development and manufacturing organization (CDMO), is entering the advanced therapy manufacturing space. The company is installing its third FlexFactory manufacturing platform from Cytiva, a Danaher company and a leader in the life sciences industry, to help meet the surging demand for advanced therapies, while maintaining their core monoclonal antibody (mAb) business.

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Sed feugiat libero eu turpis tincidunt iaculis. In vel aliquam est, at porta neque. Donec hendrerit ultrices consectetur. Integer feugiat massa quis arcu ullamcorper, tristique facilisis massa feugiat. Phasellus risus mauris, pretium vitae tortor non, tristique fringilla tortor. Aliquam volutpat eros ac risus consectetur, quis gravida erat lobortis. Quisque id rutrum enim, sed fermentum nisl. Nulla volutpat turpis ac ligula venenatis maximus. In non dui ante. Sed ullamcorper quis nisi.

Morbi faucibus sit amet dolor sit amet cursus. Quisque vulputate tellus in magna eleifend, ut luctus orci commodo.

Praesent tellus neque, maximus sit amet mauris in, fermentum pharetra ante. Sed sit amet nibh commodo, fringilla lectus ac, dictum velit. Aliquam cursus feugiat congue. Aenean sit amet enim massa. Praesent mollis sagittis est, ut accumsan eros lobortis id. Maecenas at libero ex. Proin quis est vitae tortor ullamcorper pretium eu non nunc. Quisque at lacus accumsan, finibus sapien ac, viverra ligula. Donec commodo bibendum elit sit amet posuere. Curabitur rutrum pharetra nisl, vitae tincidunt ante consectetur et.

ELEVECTA™ transient cell line

Preseves flexibility while delivering excellent performance and quality - all aimed at quickly advancing candidates to clinical trials.

  • Excellent performance: Achieve high titers of infectious virus, which you can boost further by using enhancers.
  • Enhanced product quality*: Minimize DNase-resistant host cell DNA inside capsids.
  • Innovative: Access advances in cell line engineering across the entire portfolio to support transition between cell lines.
  • Collaborative: Benefit from a comprehensive suite of regulatory support services.

ELEVECTA™ packaging cell line

Contains all genes except the transgene; allows streamlining the screaning of assets that use the same capsid to target the same tissue type.

  • Streamlined screening: Efficiently screen multiple assets that target the same tissue type.
  • Cost-effective approach: Reduce your plasmid costs with single-plasmid transfection compared with triple transfection.
  • One cell line to clinic: Go to clinic with one cell line and simplify your regulatory asks when you’re targeting the same tissue type across your programs.

ELEVECTA™ producer cell line

Contains all genes to produce AAV; simply induce. The result is a simplified, robust, upstream process that easily scales to treat hundreds of thousands.

  • Simplified manufacturing process: Replace multi-step transfection with one-step induction.
  • Easy scalability: Scale up seamlessly to achieve large quantities of AAV material.
  • Enhanced reproducibility: Produce AAV from a monoclonal cell line, enabling batch-to-batch consistency.
  • Reduced COGS: Skip the need for transfection reagent and any plasmid DNA, which are the most expensive raw materials.

Qualitative standard filter paper [2 or 3 items]

Whatman Grade 3 Qualitative Filter Papers

A standard grade filter used in qualitative analytical techniques to determine and identify materials. For use in büchner funnels.

Whatman Grade 5 Qualitative Filter Papers

A standard grade clarifying filter excellent for cloudy suspensions and for water and soil analysis.

Whatman Grade 226 Qualitative Filter Papers

A general qualitative filter with creped surface. High filtration speed, faster than grade 202 and retain coarse particles gelatinous precipitates.

Qualitative standard filter paper [3 or 4 items]

Qualitative standard filter paper

Whatman Grade 114 Qualitative Filter Papers

Whatman Grade 1575 Qualitative Filter Papers

Whatman Grade 2 Qualitative Filter Papers

Additional resources [2 or 3 items]

Protein characterization using size exclusion chromatography

Webinar

Tuesday, April 30, 2024

A standard grade clarifying filter excellent for cloudy suspensions and for water and soil analysis.

Whatman Grade 226 Qualitative Filter Papers

A standard grade filter used in qualitative analytical techniques to determine and identify materials. For use in büchner funnels.

Product carousel

Description

Product Comparison

ÄKTA go™

ÄKTA go™

Achieve desired purity with ease in routine purifications – make the most of valuable bench/cold-room space

ÄKTA pure™

ÄKTA pure™

Flexibility in research – match most current and future purification challenges

ÄKTA start™

ÄKTA start™

Entry level chromatography solution for the preparative purification of proteins in lab scale.

ÄKTA oligosynt™

ÄKTA oligosynt™

Compact, fully automated oligonucleotide synthesizer to support research and process development laboratories.

Support for affinity chromatography, ion exchange chromatography, and multimodal (mixed mode) chromatography yes yes yes yes
Support for affinity chromatography, ion exchange chromatography, multimodal (mixed mode) and size exclusion chromatography yes yes no no
Support for hydrophobic interaction chromatography yes yes yes no
Scale up, method development and optimisation using design of experiment (DoE) no yes yes yes
Automated: resin/column scouting, multistep purification, external equipment no yes no yes
Wavelength (nm) Fixed at 280nm Optional Fixed at 280, dual 260/280 or multi – up to 3 between 190-700 Fixed at 280nm Optional Fixed at 280, dual 260/280 or multi – up to 3 between 190-700
Recommended flow rate (mL/min) 0.01-25.0 0.001-25/0.01-150 0.01-25.0 0.001-25/0.01-150
Maximum operating pressure (Mpa) 5 20/5 7 20/4

    Rapidly deployable mRNA FlexFactory™ facility

    In this video, you’ll get a behind-the-scenes look at how KUBio box trailer supports the evolving needs of advanced therapy manufacturers. From rapid deployment and modular design to integrated bioprocessing and digital control, KUBio box trailer is engineered to help you launch faster, operate smarter, and stay compliant.

    Thank you for your interest! Here is your digital goodie bag from Cytiva.

    Agenda

    On the third day, we will welcome you all to Sweden at the site for a reception lunch. Have a bite to eat and chat with us and other attendees. Once fed and settled, we will commence the first workshops of the week. Simultaneously, a second group will be taken to the Cytiva Uppsala site to see where the magic happens.

    Time Details
    8:30 - 9:15 Registration
    9:25 - 10:40 Nestor Santiago and Gillian Goodwin Biacore™ system assay development revisited - Recipe for successful SPR data
    10:50 - 12:20 Cynthia Shuman and Eric Roush Slow and steady wins the race: Techniques for measuring slow dissociation rates using Biacore SPR system
    12:30 - 14:30 Lunch break
    14:45 - 16:00 Christin Radon and Emeric Gueneau Thinking outside 1:1 – Discover how to approach assay design for induced proximity and targeted protein degradation
    16:10 - 16:40 Anja Drescher and Mike Murphy Facilitating comparability with SPR-based surrogate potency assays and sensorgram comparison
    16:50 - 17:20 John Sinfield and Shannon Bryan Biacore™ Insight Software – A look beneath the surface: interesting facts and hidden features that will improve your workflows from start to finish

    Technical deep dive:

    Cell therapy resources

    Regulatory: US preclinical study of cellular and gene therapies

    This free interactive course provides a high-level overview of preclinical study in cellular and gene therapy (CGT) development.

    Our location

    Testimonials