Advancing future therapeutics

Buffer preparation is still a highly manual activity in the biopharmaceutical industry that often requires a lot of resources due to the large number and overall volume of buffers and process liquids used in a typical bioprocess workflow.

In biomanufacturing, seven out of the ten downstream equipment types with the longest occupancy duration are buffer related. Holding tanks reserved for buffers also require significant floor space in large-scale production facilities that could be used for other core operations.

As a result, buffer preparation can create bottlenecks in the manufacturing process.

Most companies are still relying on the traditional ways of preparing buffers, but there are more modern, alternative buffer preparation methods that can bring significant savings and efficiency improvements while ensuring high quality.

It is critical that every process is evaluated for the optimal buffer management strategy as there is no one solution that fits all processes.

For example, outsourced premade buffers can be a simple and fast way to gain new capacity, especially in process development and in “downsized” single-use facilities, providing speed-to-market and flexibility.

With inline conditioning and inline dilution, where buffers are prepared in-line from buffer concentrates or stock solutions, buffer preparation can be directly integrated with the chromatography or filtration step. This eliminates the need for intermediate storage in buffer bags or holding tanks, bringing significant reductions in floor space and tank volumes with increased automation.

In this webinar you will learn:
• Advantages, sweet spots, and drawbacks with the different buffer preparation approaches through real-life, data-driven examples
• Important considerations for choosing the right buffer management strategy
• How to assure consistent buffer quality with inline dilution and inline conditioning, or when outsourcing buffers
• What are the technical capabilities focusing on quality that are built into these approaches?
• Buffer management trends and biopharmaceutical companies’ long term-strategies for the future

Jenny holds a Master of Science in Molecular biotechnology engineering from Uppsala University, Sweden. She started her career in the Life Science and Medical Technology areas with different positions within marketing, sales and application support. In 2015, she joined Cytiva as Global Product Marketing Manager for the downstream hardware portfolio and was the marketing lead for the launch of the successful ÄKTA pilot 600. In 2018, she moved to the product management organization. Jenny is inspired by people and is always eager to learn and use her creative mind.

As a Global Product Manager with the ready-made Process Liquids and Buffers portfolio, Alexander has been exposed to many customers that all have the common challenge of managing buffers in a rapidly growing environment while simultaneously trying to maximize current efficiencies.
Alexander’s background is well rounded as he completed his doctorate in Cell and Tissue engineering at the University of Illinois at Chicago in the Bioengineering department. Thereafter, he joined Baxter Healthcare as an R&D Global Project Leader and worked in three separate locations while leading global programs in device development and clinical program management, moving to Austria in the process.