What are the top strategic imperatives in manufacturing?

Decisions on choosing a platform fit for your needs: Carefully evaluate both CapEx and OpeX costs, capacity, utilization and other parameters

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Would you like connect with the team behind these numbers?

ELEVECTA™ cell line portfolio for AAV manufacturing

Beyond supporting your gene therapy processes with our technology and application knowledge, we're passionate about advancing solutions in areas where the status quo isn’t good enough. That's why we're excited to tell you about our ELEVECTA™ cell lines ― a significant advancement in viral vector manufacturing.

Process modeling can help assess impact of process setup to some of these top imperatives – cost of goods sold, capacity, utilization and sustainability. Connect with the team behind the numbers to explore:

Comparisons of manufacturing costs across stainless steel, single-use, and continuous
When scaling up has similar effect as scaling out for COGS
When stainless steel fed-batch can achieve larger cost benefits than scaling out
How to mitigate against high costs associated with low utilization of resin lifetime
Analysis of the additional costs in media prep

SUPRAdisc™ II depth filter modules

Next generation in depth filter module technology for bioprocess clarification applications.

The SUPRAdisc™ II module design combines the filtration performance of Seitz™ media and the structural robustness of interlocking dual drainage plates.

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The ELEVECTA™ cell line portfolio combines innovative design and deep expertise to deliver transient, packaging, and producer options that provide competitive performance, high quality, and flexibility.

Fit for purpose: Choose the option that makes sense for your stage, asset mix, and organizational goals.
Flexible: Enjoy competitive terms and the freedom to transition between cell lines as needs evolve.
Enhanced product quality*: Minimize host cell DNA inside capsids, which is resistant to nucleases.
Innovative: Access advances in cell line engineering informed by deep industry know-how.
Collaborative: We’re more than a supplier. Benefit from a comprehensive suite of regulatory support services designed to expedite your success in advancing to and through clinical trials.

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Scale-out scenarios

Base-case scenarios for comparison of manufacturing costs

ELEVECTA™ transient cell line

Preseves flexibility while delivering excellent performance and quality - all aimed at quickly advancing candidates to clinical trials.

Excellent performance: Achieve high titers of infectious virus, which you can boost further by using enhancers.
Enhanced product quality*: Minimize DNase-resistant host cell DNA inside capsids.
Innovative: Access advances in cell line engineering across the entire portfolio to support transition between cell lines.
Collaborative: Benefit from a comprehensive suite of regulatory support services.

ELEVECTA™ packaging cell line

Contains all genes except the transgene; allows streamlining the screaning of assets that use the same capsid to target the same tissue type.

Streamlined screening: Efficiently screen multiple assets that target the same tissue type.
Cost-effective approach: Reduce your plasmid costs with single-plasmid transfection compared with triple transfection.
One cell line to clinic: Go to clinic with one cell line and simplify your regulatory asks when you’re targeting the same tissue type across your programs.

ELEVECTA™ producer cell line

Contains all genes to produce AAV; simply induce. The result is a simplified, robust, upstream process that easily scales to treat hundreds of thousands.

Simplified manufacturing process: Replace multi-step transfection with one-step induction.
Easy scalability: Scale up seamlessly to achieve large quantities of AAV material.
Enhanced reproducibility: Produce AAV from a monoclonal cell line, enabling batch-to-batch consistency.
Reduced COGS: Skip the need for transfection reagent and any plasmid DNA, which are the most expensive raw materials.