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From concept to clinic: services for pDNA, mRNA, and LNPs

Our process development and formulation services from Cytiva help biotech companies accelerate their molecules through clinical development. With global reach and deep scientific expertise, we offer solutions and delivery technologies across plasmid DNA (pDNA), mRNA, and lipid nanoparticles (LNPs). Our experienced scientists will work closely with customers to set goals and manage their projects of any size with full transparency. We will support their molecule’s manufacturability, upskill their team with training and education, and transfer all process knowledge to them—until we cross the finish line together. Customers can think of us as an extension of their team.

Applications:

ELEVECTA™ transient cell line

Preseves flexibility while delivering excellent performance and quality - all aimed at quickly advancing candidates to clinical trials.

• Excellent performance: Achieve high titers of infectious virus, which you can boost further by using enhancers.
• Enhanced product quality*: Minimize DNase-resistant host cell DNA inside capsids.
• Innovative: Access advances in cell line engineering across the entire portfolio to support transition between cell lines.
• Collaborative: Benefit from a comprehensive suite of regulatory support services.

ELEVECTA™ packaging cell line

Contains all genes except the transgene; allows streamlining the screaning of assets that use the same capsid to target the same tissue type.

• Streamlined screening: Efficiently screen multiple assets that target the same tissue type.
• Cost-effective approach: Reduce your plasmid costs with single-plasmid transfection compared with triple transfection.
• One cell line to clinic: Go to clinic with one cell line and simplify your regulatory asks when you’re targeting the same tissue type across your programs.

ELEVECTA™ producer cell line

Contains all genes to produce AAV; simply induce. The result is a simplified, robust, upstream process that easily scales to treat hundreds of thousands.

• Simplified manufacturing process: Replace multi-step transfection with one-step induction.
• Easy scalability: Scale up seamlessly to achieve large quantities of AAV material.
• Enhanced reproducibility: Produce AAV from a monoclonal cell line, enabling batch-to-batch consistency.
• Reduced COGS: Skip the need for transfection reagent and any plasmid DNA, which are the most expensive raw materials.