MabSelect VH3 and MabSelect VL resins

Pall Life Sciences is now part of Cytiva!

Say Hello to MabSelect™ VH3, MabSelect™ VL,

and MabSelect PrismA™ resins

Improve efficiency in capture of antibody variants

Bispecifics. Antibody fragments. As the therapeutic pipeline diversifies, chromatography toolboxes are expanding.

Watch this video to learn about how purification platforms used for many traditional mAbs needs to be adopted for antibody variants to simplify protocols and improve purity and yield.

Cytiva affinity resins for efficient separation of antibody variants in the capture step

Fig 1. DBC at 10% breakthrough (Q_B10) vs residence time of MabSelect™ VH3 resin for mAb, Fab, and VHH.

Fig 2. DBC at 10% breakthrough (Q_B10) vs residence time of MabSelect™ VL protein L resin for mAb, Fab, and dAb.

Fig 3. Relative remaining DBC using 0.5 M NaOH as cleaning agent at 15 min contact time between cycles.

MabSelect™ VH3 resin
MabSelect™ VH3 affinity resin uses an engineered protein A ligand that interacts only with the variable heavy chain containing the VH3 sequence family. This interaction enables efficient separation of bispecific antibodies (bsAb), Fab, scFv, and VHH.

MabSelect™ VL resin
MabSelect™ VL resin has a redesigned protein L ligand that provides high binding capacity and improved alkaline stability for affinity capture of antibody Fabs, bispecifics, and other variants containing a kappa light chain.

MabSelect PrismA™ resin

MabSelect PrismA™ protein A chromatography resin has enhanced alkaline stability and binding capacity for improved process economy in purification of mAb and bsAb.

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