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Investigating cell-free DNA in liquid biopsy

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Liquid biopsy will be a game changer for personalized medicine

Cell-free DNA (cfDNA) is currently trending as a biomarker from liquid biopsy in several clinical applications, including oncology, organ and transplant medicine, and non-invasive prenatal testing (NIPT).

cfDNA is unencapsulated DNA freely circulating the bloodstream, including circulating tumor DNA (ctDNA) and cell-free fetal DNA (cffDNA). Due to the small amount of cfDNA found in circulation, there is a need to use efficient, highly sensitive technologies, such as NGS, to detect these biomarkers.

This white paper discusses the challenges and opportunities in measuring cfDNA from liquid samples.

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